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Journal Articles

Adsorption of $^{188}$ Re complexes with aminomethylenephosphonate on hydroxyapatite

Hashimoto, Kazuyuki; Matsuoka, Hiromitsu; Izumo, Mishiroku

Journal of Nuclear and Radiochemical Sciences, 2(1-2), p.5 - 9, 2001/12

https://doi.org/10.14494/jnrs2000.2.5

The radioactive rhenium complexes with phosphonate-containing ligands are good bone seeking compounds, and have been developed for the palliative treatment of metastatic bone pain. In this paper, we describe the adsorption properties of newly developed $^{188}$ Re complexes with aminomethylenephosphonate ( $^{188}$ Re-EDTMP, EDBMP and NTMP) on hydroxyapatite, which is the major constituent of the hard tissues of bone. The influence of the shaking time, pH and the ionic strength on the adsorption was investigated. The adsorption of $^{188}$ Re complexes was strongly affected by pH and ionic strength in a solution. The adsorption coefficient increased with decreasing pH and ionic strength. These observations suggest that one of the causes of the adsorption of $^{188}$ Re-amp is considered the electrostatic forces between the negative Re-amp complex and the positive HAP surface. The adsorption affinity of the $^{188}$ Re-amp complex for HAP increased in the order $^{188}$ Re-EDBMP $<^{188}$ Re-NTMP $<^{188}$ Re-EDTMP.